(2R,3R,11R,12R)-(+)-18-crown-6-2,3,11,12-tetracarbonic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid
Nonfluorochemicals, Crown ethers
KUMI0F229
61696-54-6
MFCD00040514
3082976
1671540
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(2R,3R,11R,12R)-(+)-18-crown-6-2,3,11,12-tetracarbonic acid
C16H24O14
440.35
≥98%
White to Off-white Solid
210-212°C
5g,10g,20g,50g,100g,500g,1kg,5kg,10kg and 25kg
Store at 2-8 temp.
(+)-(18-Crown-6)-2,3,11,12-tetracarboxylic acid is a chiral crown ether that is generally used in capillary liquid chromatography (CLC) and capillary electrochromatography (CEC). It has been successfully used as a chiral selector in capillary zone electrophoresis for the separation of a variety of optically active amines.
18-Crown-6-Tetracarboxylic acid as a chiral additive for the simultaneous separation of o-, m- and p-enantiomers of phenylalanine family by capillary electrophoresis. [1] 
Comparison of enantiomer separation on two chiral stationary phases derived from (+)-18-crown-6-2,3,11,12-tetracarboxylic acid of the same chiral selector. [2] 
Enantioseparations of primary amino compounds by high-performance liquid chromatography using chiral crown ether-based chiral stationary phase. [3] 
Enantiomeric discrimination of isoxazoline fused β-amino acid derivatives using (18-Crown-6)-2,3,11,12-tetracarboxylic acid as a chiral NMR solvating agent. [4] 
References:
[1] Z.Chen, et al, Enantiomer, 2001, 6(1), pp 19-25.
[2] W.Lee, et al, Microchem. J., 2005, 80(2), pp 213-217.
[3] M.H.Hyun, et al, Methods Mol. Biol., 2013, 970, pp 165-176.
[4] J.A.Howard, et al, Chirality, 2013, 25(1), pp 48-53.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
29329900900
NONH for all modes of transport

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