(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(1S,2S)-(+)-1,2-Bis(methylamino)cyclohexane
Non-Fluorochemicals, API & Intermediates
KUMI0F1023
87583-89-9

PubChem ID

Reax
MFCD00671528

PubChem ID
13822957
4304824
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine
C8H18N2
142.24
≥98%
White to Yellow Solid
39-44°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine (also named as (1S,2S)-(+)-1,2-Bis(methylamino)cyclohexane) is typically used in the preparation of PF-07059013, a noncovalent modulator of hemoglobin for treatment of sickle cell disease.
Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids. [1]
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease. [2]
References:
[1] C.Han, et al, Tetrahedron, 2019, 75(32), pp 4359-4357.
[2] A.Gopalsamy, et al, J. Med. Chem., 2021, 64(1), pp 326-342.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302,H314
P260,P280,P301+P312+P330,P303+P361+P353,P305+P351+P338+P310
29213099
UN 3259 8/PG II

1. Product Specification
2. Safety Data Sheet
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