(2,2-Dimethylpropyl)-[2-methyl-2-(4-nitroimidazol-1-yl)propyl]amine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Methyl-2-(4-nitroimidazol-1-yl)propyl]-neopentyl-amine
Non-Fluorochemicals, API & Intermediates
KUMI0F996
865774-15-8

PubChem ID

Reax
 

PubChem ID
67164086
14456421
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(2,2-Dimethylpropyl)-[2-methyl-2-(4-nitroimidazol-1-yl)propyl]amine
C12H22N4O2
254.33
≥98%
White to Off-white Solid

10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
(2,2-Dimethylpropyl)-[2-methyl-2-(4-nitroimidazol-1-yl)propyl]amine is an intermediate primarily used in the preparation of Nirogacestat (PF-03084014), a selective gamma-secretase inhibitor for the treatment of desmoid tumors that cannot be removed by surgery.
Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. [1]
Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. [2]
Safety and efficacy of gamma-secretase inhibitor nirogacestat (PF-03084014) in desmoid tumor: Report of four pediatric/young adult cases. [3]
References:
[1] P.Wei, et al, Mol. Cancer Ther., 2010, 9(6), pp 1618-1628.
[2] C.C.Zhang, et al, Clin. Cancer Res., 2012, 18(18), pp 5008-5019.
[3] T.Takahashi, et al, Pediatr. Blood Cancer, 2020, 67(10):e28636.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P305+P352,P305+P351+P338
29332990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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