2-(4,6-Dimethyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole is a heterocycle intermediate typically used in the preparation of Seltorexant (former developmental code names MIN-202, JNJ-42847922, JNJ-922) is a selective, small-molecule antagonist of the OX2 receptor for the treatment of insomnia and major depressive disorder (MDD).
Small-molecule antagonists of the orexin receptors. [1]
Discovery and development of orexin receptor antagonists as therapeutics for insomnia. [2]
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