2,4-Dichloro-3-nitropyridine (also named as 2,4-Bis(chloranyl)-3-nitro-pyridine) is a heterocyclic intermediate typically used in the preparation of Tolebrutinib (SAR442168), a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK).
Efficient synthesis of AMP579, a novel Adenosine A1/A2 receptor agonist.[1]
Radiosynthesis of a Bruton's tyrosine kinase inhibitor, [11 C]Tolebrutinib, via palladium-NiXantphos-mediated carbonylation.[2]
References:
[1] A.W.Sledeski, et al, J. Org. Chem., 2000, 65(23), pp 8114-8118.
[2] K.Dahl, et al, J. Labelled Comp. Radiopharm., 2020, 63(11), pp 482-487.
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293329000
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