2,4-Dichlorophenylboronic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,4-Dichlorobenzeneboronic acid, 2,4-Dichlorobenzeneboron dihydroxide
Nonfluorochemicals
KUMI0F369
68716-47-2
MFCD00013930
4983878
2734659
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2,4-Dichlorophenylboronic acid
C6H5BCl2O2
190.82
≥98%
White to Off-White Solid
246-249°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
2,4-Dichlorophenylboronic acid (also named as 2,4-Dichlorobenzeneboronic acid, 2,4-Dichlorobenzeneboron dihydroxide ) is a useful intermediate typically used in the synthesisi of biologically active molecules including: N-hydroxyindole-2-carboxylates for use as lactate dehydrogenase inhibitors
,non-ATP competitive MK2 inhibitors and nonsteroidal selective estrogen receptor degrader/downregulator (SERD).
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation. [1]
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors. [2]
Dose-escalation study of SAR439859, an oral selective estrogen receptor (ER) degrader (SERD), in postmenopausal women with ER+/HER2- metastatic breast cancer (mBC). [3]
References:
[1] C.Granchi, et al, Eur. J. Med. Chem., 2011, 46(11), pp 5398-5407.
[2] X.Huang, et al, ACS Med. Chem. Lett., 2011, 2(8), pp 632-637.
[3] A.Bardia, et al, J. Clin. Oncol, 2019, 37(15), pp 1054-1054.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a hazardous substance or mixture
 
 
2931900090
NONH for all modes of transport

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