2,6-Dichloro-7-deazapurine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Non-Fluorochemicals, API & Intermediates
KUMI0F977
90213-66-4

PubChem ID

Reax
MFCD08059278

PubChem ID
14116871
5258274
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2,6-Dichloro-7-deazapurine
C6H3Cl2N3
188.01
≥98%
White to Brown Solid
249-253°C
10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
2,6-Dichloro-7-deazapurine (also named as 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine) is typically used in the preparation of Ritlecitinib (PF-06651600), an orally active and selective JAK3 inhibitor for the treatment of Alopecia areata, Crohn's disease, Rheumatoid arthritis, Ulcerative colitis and Vitiligo.
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. [1]
Process Development and Scale up of a Selective JAK3 Covalent Inhibitor PF-06651600. [2]
References:
[1] J-B. Telliez, et al, ACS Chem. Biol., 2016, 11(12), pp 3442-3451.
[2] Y.Tao, et al, Org. Process Res. Dev., 2019, 23(9), pp 1872-1880.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
2933998290
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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