2-Bromo-1-cyclopropylethanone is an intermediate commonly used in the prepartion of some pharmaceutically active substances, such as potent and selective human A3 adenosine receptor antagonists and apoptosis sigsomenal-regulating kinase 1 (ASK1) inhibitors.
New Pyrrolo[2,1-f]purine-2,4-dione and Imidazo[2,1-f]purine-2,4-dione Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. 
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. 
 P.G.Baraldi, et al, J. Med. Chem., 2005, 48(14), pp 4697-4701.
 N.Ji, et al, Cancer Lett., 2019, 440-441, pp 82-93.
UN 2811 6.1/PG III
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