2-Bromo-3-picoline

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Bromo-3-methyl-pyridine
Nonfluorochemicals, API&Intermediates
KUMI0F280
3430-17-9
MFCD00239380

Rea
220832

Reax
107896
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
2-Bromo-3-picoline
C6H6BrN
172.02
98%
Colorless to Pale Yellow Liquid
218-219°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
2-Bromo-3-picoline (also named as 2-Bromo-3-methyl-pyridine) is a heterocyclic building block that commonly used in organic synthesis. An example is empolyed in the preparation of VX-770 and VX-809 as potent CFTR correctors for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation.
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. [1]
Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809. [2]
References:
[1] F.Van Goor, et al, Proc. Natl. Acad. Sci. USA, 2011, 108(46), pp 18843-18848.
[2] J.E.Doiron, et al, Chemistry, 2019, 25(14), pp 3662-3674.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933399990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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