2-Bromo-5H-pyrrolo[2,3-b]pyrazine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-Bromo-4,7-diazaindole
Nonfluorochemicals, API&Intermediates
KUMI0F290
875781-43-4
MFCD09834822

Rea
25067308

Reax
14515666
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-Bromo-5H-pyrrolo[2,3-b]pyrazine
C6H4BrN3
198.02
98%
Yellow to Brown Solid

5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
2-Bromo-5H-pyrrolo[2,3-b]pyrazine is a heterocyclic intermediate that commonly used in the preparation of various drug substances. A typcial example is employed for the synthesis of ABT-494 as a potent and selective JAK inhibitors in the treatment of Rheumatoid Arthritis and an Inadequate Response to Methotrexate.
3-amido pyrrolopyrazine JAK kinase inhibitors: Development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models. [1]
Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. [2]
Efficacy and Safety of ABT-494, a Selective JAK-1 Inhibitor, in a Phase IIb Study in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate. [3]
A Phase IIb Study of ABT-494, a Selective JAK-1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti-Tumor Necrosis Factor Therapy. [4]
Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors. [5]
References:
[1] M.Soth, et al, J. Med. Chem., 2013, 56(1), pp 345-356.
[2] D.J.Burdick, et al, Bioorg. Med. Chem. Lett., 2015, 25(21), pp 4728-4732.
[3] M.C.Genovese, et al, Arthritis Rheumatol., 2016, 68(12), pp 2857-2866.
[4] J.M.Kremer, et al, Arthritis Rheumatol., 2016, 68(12), pp 2867-2877.
[5] N.Pemberton, et al, J. Med. Chem., 2018, 61(12), pp 5435-5441.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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