2-Chloro-4-methyl-6-(methylthio)pyrimidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Chloro-4-methyl-6-methylsulfanylpyrimidine
Nonfluorochemicals, API&Intermediates
KUMI0F250
89466-59-1
MFCD09832937
3047723
21030351
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-Chloro-4-methyl-6-(methylthio)pyrimidine
C6H7ClN2S
174.65
≥98%
White to Yellow Solid
72-73°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
2-Chloro-4-methyl-6-(methylthio)pyrimidine is a pyrimidine intermediate typically used in the prepartion of BLU-667 as a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. [1]
Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. [2]
References:
[1] V.Subbiah, et al, Cancer Discov., 2018, 8(7), pp 836-849.
[2] Z.Piotrowska, et al, Cancer Discov., 2018, 8(12), pp 1529-1539.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H332,H403
P309+P311,P211,P242,P305+P351+P338
2933599090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.