2-Cyano ethyl acetoacetate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Cyanoethyl 3-oxobutanoate
Non-Fluorochemicals, API & Intermediates
KUMI0F1016
65193-87-5

PubChem ID

Reax
MFCD24687999

PubChem ID
2723974
12360406
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
2-Cyano ethyl acetoacetate
C7H9NO3
155.15
≥95%
Colorless to Yellow Liquid
115°C/1.5mmHg
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
2-Cyano ethyl acetoacetate (also known as 2-Cyanoethyl 3-oxobutanoate) is an intermediate typically used in the preparation of Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist.
Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. [1]
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1. [2]
References:
[1] L.Barfacker, et al, ChemMedChem, 2012, 7(8), pp 1385-1403.
[2] L.Amezit, et al, J. Biol. Chem., 2015, 290(36), pp 21876-21889.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated


29153990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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