3,5-Dichloro-4-methylpyridine (also named as 3,5-Dichloro-4-picoline) is typically used in the preparation of CHF6001, a novel highly potent and selective phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease (COPD).
Process development of the PDE4 inhibitor K-34.
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.
Synthesis of 14C- and 2H-labelled CHF6001: A new potent PDE4 inhibitor. 
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