3-Amino-5-methylpyrazole was employed as beta-sheet template to investigate its interaction with ferrocenoyl-dipeptides. It is recently used in the prepartion of BLU-667 as a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
Interaction of ferrocenoyl-dipeptides with 3-aminopyrazole derivatives: beta-sheet models? A synthetic, spectroscopic, structural, and electrochemical study. 
Characterization of peptide-pyrazole interactions in solution by low-temperature NMR studies. 
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. 
Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. 
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 V.Subbiah, et al, Cancer Discov., 2018, 8(7), pp 836-849.
 Z.Piotrowska, et al, Cancer Discov., 2018, 8(12), pp 1529-1539.
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