3-Amino-5-methylpyrazole

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-Methyl-3-pyrazolamine
Nonfluorochemicals, API&Intermediates
KUMI0F251
31230-17-8
MFCD00075180
93146
1904
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-Amino-5-methylpyrazole
C4H7N3
97.12
≥98%
Light Yellow to Yellow Solid
45-47°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
3-Amino-5-methylpyrazole was employed as beta-sheet template to investigate its interaction with ferrocenoyl-dipeptides. It is recently used in the prepartion of BLU-667 as a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
Interaction of ferrocenoyl-dipeptides with 3-aminopyrazole derivatives: beta-sheet models? A synthetic, spectroscopic, structural, and electrochemical study. [1]
Characterization of peptide-pyrazole interactions in solution by low-temperature NMR studies. [2]
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. [3]
Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. [4]
References:
[1] P.Saweczko, et al, Inorg. Chem., 2001, 40(17), pp 4409-4419.
[2] W.Wang, et al, Chemistry, 2007, 13(3), pp 854-861.
[3] V.Subbiah, et al, Cancer Discov., 2018, 8(7), pp 836-849.
[4] Z.Piotrowska, et al, Cancer Discov., 2018, 8(12), pp 1529-1539.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933199090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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