3-Amino-5-methylpyrazole was employed as beta-sheet template to investigate its interaction with ferrocenoyl-dipeptides. It is recently used in the prepartion of BLU-667 as a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
Interaction of ferrocenoyl-dipeptides with 3-aminopyrazole derivatives: beta-sheet models? A synthetic, spectroscopic, structural, and electrochemical study. 
Characterization of peptide-pyrazole interactions in solution by low-temperature NMR studies. 
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. 
Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. 
 P.Saweczko, et al, Inorg. Chem., 2001, 40(17), pp 4409-4419.
 W.Wang, et al, Chemistry, 2007, 13(3), pp 854-861.
 V.Subbiah, et al, Cancer Discov., 2018, 8(7), pp 836-849.
 Z.Piotrowska, et al, Cancer Discov., 2018, 8(12), pp 1529-1539.
NONH for all modes of transport
1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email firstname.lastname@example.org.