3-Amino-6-methoxypyridazine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
6-Methoxypyridazin-3-amine
Nonfluorochemicals, API&Intermediates
KUMI0F257
7252-84-8
MFCD01646127
15541848
81673
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-Amino-6-methoxypyridazine
C5H7N3O
125.13
≥98%
White to Beige Solid
103-105°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
3-Amino-6-methoxypyridazine is a heterocyclic intermediate that commonly used in the preparation of various pharmaceutically active substances, such as TAK-385, a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist administered orally in the treatment of uterine fibroids.
Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor. [1]
Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen. [2]
References:
[1] K.Miwa, et al, J. Med. Chem., 2011, 54(14), pp 4998-5012.
[2] T.A.Alanine, et al, Org. Biomol. Chem., 2016, 14(3), pp 1031-1038.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P271,P280
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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