3-Methyl-1H-pyrazole-4-boronic acid pinacol ester

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
Non-Fluorochemicals, API & Intermediates
KUMI0F1024
936250-20-3

PubChem ID

Reax
MFCD08690235

PubChem ID
17750270
18319101
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-Methyl-1H-pyrazole-4-boronic acid pinacol ester
C10H17BN2O2
208.07
≥98%
White to Yellow Solid
129-134°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
3-Methyl-1H-pyrazole-4-boronic acid pinacol ester (also named as 3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole) is typically used in the preparation of PF-07059013, a noncovalent modulator of hemoglobin for treatment of sickle cell disease.
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets. [1]
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease. [2]
References:
[1] J.Magalhaes, et al, J. Chem. Int. Model, 2018, 58(3), pp 710-723.
[2] A.Gopalsamy, et al, J. Med. Chem., 2021, 64(1), pp 326-342.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P302+P352,P305+P351+P338
29349990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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