3-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-Methyl-1(2)H-pyrazolo[3,4-d]pyrimidin-4-ylamine
Non-Fluorochemicals, API & Intermediates
KUMI0F1021
5399-44-0

PubChem ID

Reax
MFCD13813768

PubChem ID
219854
8535
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
C6H7N5
149.16
≥98%
Off-white to Yellow Solid
300-310°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
3-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine is typically used in the preparation of Parsaclisib (INCB050465), a potent, selective and orally active inhibitor of PI3K.
Identifying New Drug Targets for Potent Phospholipase D Inhibitors: Combining Sequence Alignment, Molecular Docking, and Enzyme Activity/Binding Assays. [1]
INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ). [2]
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy. [3]
References:
[1] H.Djakpa, et al, Chem. Biol. Drug Res., 2016, 87(5), pp 714-729.
[2] E.W.Yue, et al, ACS Med. Chem. Lett., 2019, 10(11), pp 1554-1560.
[3] N.Shin, et al, J. Pharmacol. Exp. Ther., 2020, 374(1), pp 211-222.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302+312+332,H315,H319,H335
P271,P260,P280,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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