4-(8-Quinolinylsulfonylamino)benzoic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-(Quinoline-8-sulfonamido)benzoic acid
Non-Fluorochemicals, API & Intermediates
KUMI0F994
116834-64-1

PubChem ID

Reax
MFCD00601229

PubChem ID
776645
15405867
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-(8-Quinolinylsulfonylamino)benzoic acid
C16H12N2O4S
328.35
≥98%
White to Yellow Solid
260-269°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
4-(8-Quinolinylsulfonylamino)benzoic acid is an intermediate typically used in the preparation of Mitapivat (AG-348), an activator of a pyruvate kinase PKM2 for the treatment of  Pyruvate Kinase (PK) Deficiency.
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. [1]
The design of potent HIV-1 integrase inhibitors by a combined approach of structure-based virtual screening and molecular dynamics simulation. [2]
AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. [3]
References:
[1] C.Kung, et al, Blood, 2017, 130(11), pp 1347-1356.
[2] A.S.Samorlu, et al, J. Biomol. Struct. Dyn., 2019, 37(17), pp 4644-4650.
[3] M.A.E.Rab, et al, Haematologica, 2020, DOI: 10.3324/haematol.2019.238865.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
2935009090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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