4-Amino-3-bromo-5-nitropyridine is a pharmaceutial intermediate that typically in the preparation of SM-04690, a small-molecule inhibitor of the Wnt pathway which is being investigated as a potential disease modifying agent for the treatment of osteoarthritis of the knee.
A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study. 
A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee. 
 Y.Yazici, et al, Osteoarthritis Cartilage, 2017, 25(10), pp 1598-1606.
 V.Deshmukh, et al, Osteoarthritis Cartilage, 2018, 26(1), pp 18-27.
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