4-Amino-5-methylpyridin-2(1H)-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Amino-2-hydroxy-5-methylpyridine
Non-Fluorochemicals, API & Intermediates
KUMI0F1018
95306-64-2

PubChem ID

Reax
MFCD12546373

PubChem ID
13295732
4378830
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-Amino-5-methylpyridin-2(1H)-one
C6H8N2O
124.14
≥98%
White to Yellow Solid
292-304°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
4-Amino-5-methylpyridin-2(1H)-one (also known as 4-Amino-2-hydroxy-5-methylpyridine) is an intermediate typically used in the preparation of Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist.
Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. [1]
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1. [2]
References:
[1] L.Barfacker, et al, ChemMedChem, 2012, 7(8), pp 1385-1403.
[2] L.Amezit, et al, J. Biol. Chem., 2015, 290(36), pp 21876-21889.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated


29333990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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