4-Bromo-6-methoxypyrazolo[1,5-a]pyridine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Bromanyl-6-methoxy-pyrazolo[1,5-a]pyridine
Nonfluorochemicals, API&Intermediates
KUMI0F287
1207839-86-8
MFCD22689926

Rea
44816598

Reax

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-Bromo-6-methoxypyrazolo[1,5-a]pyridine
C8H7BrN2O
227.06
98%
White to Yellow Solid
42-46°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
4-Bromo-6-methoxypyrazolo[1,5-a]pyridine is a heterocyclic intermediate that typically used in the preparation of LOXO-292 as a selective and potent RET kinase inhibitor for the treatment of RET fusion-positive and RET-mutant cancers alike.
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors. [1]
Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities for α4β2 neuronal nicotinic acetylcholine receptors. [2]
Selective RET kinase inhibition for patients with RET-altered cancers. [3]
LOXO-292 Reins In RET-Driven Tumors. [4]
References:
[1] G.Murineddu, et al, Bioorg. Med. Chem. Lett., 2008, 18(23), pp 6147-6152.
[2] F.Deligia, et al, Eur. J. Med. Chem., 2015, 103, pp 429-437.
[3] V.Subbiah, et al, Ann. Oncol., 2018, 29(8), pp 1869-1876.
[4] No authors listed, Cancel Discov., 2018, 8(8), pp 904-905.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933599590
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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