4-Methoxy-1H-indole-2-carboxylic acid (also known as 4-Methoxy-indol-2-carbonsaeure) is typically used as a key intermediate for the preparation of PF-00835231, which is a potent inhibitor of coronavirus 3CL proteases or the potential therapeutic treatment of COVID-19.
Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies. 
Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D 2 Receptor. 
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. 
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 A.Kopinathan, et al, J. Med. Chem., 2019, 62(1), pp 371-377.
 R.L.Hoffman, et al, J. Med. Chem., 2020, XXXX, XXX, XXX-XXX.
NONH for all modes of transport
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