4-Methoxy-1H-indole-2-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Methoxy-indol-2-carbonsaeure
Non-Fluorochemicals, API & Intermediates
KUMI0F999
103260-65-7

PubChem ID

Reax
MFCD02664458

PubChem ID
907248
168426
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-Methoxy-1H-indole-2-carboxylic acid
C10H9NO3
191.19
≥98%
White to Yellow Solid
240-241°C
10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
4-Methoxy-1H-indole-2-carboxylic acid (also known as 4-Methoxy-indol-2-carbonsaeure) is typically used as a key intermediate for the preparation of PF-00835231, which is a potent inhibitor of coronavirus 3CL proteases or the potential therapeutic treatment of COVID-19.
Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies. [1]
Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-(( trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D 2 Receptor. [2]
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. [3]
References:
[1] P.Thanigaimalai, et al, Eur. J. Med. Chem., 2013, 68, pp 372-384.
[2] A.Kopinathan, et al, J. Med. Chem., 2019, 62(1), pp 371-377.
[3] R.L.Hoffman, et al, J. Med. Chem., 2020, XXXX, XXX, XXX-XXX.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
29339980
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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