4-Oxo-1,4-dihydroquinoline-3-carboxylic acid is a heterocyclic building block that commonly used in organic synthesis. An example is empolyed in the preparation of VX-770 as a potent CFTR corrector for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation.
Tautomerism and Magnesium Chelation of HIV-1 Integrase Inhibitors: A Theoretical Study. 
Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809. 
 C.Liao, et al, ChemMedChem, 2010, 5(7), pp 1053-1066.
 J.E.Doiron, et al, Chemistry, 2019, 25(14), pp 3662-3674.
NONH for all modes of transport
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