4-Oxo-1,4-dihydroquinoline-3-carboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1,4-Dihydro-4-oxoquinoline-3-carboxylic acid
Nonfluorochemicals, API&Intermediates
KUMI0F281
13721-01-2
MFCD00498984

Rea
220875

Reax
474474
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-Oxo-1,4-dihydroquinoline-3-carboxylic acid
C10H7NO3
189.17
98%
White to Off-white Solid
251-253°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
4-Oxo-1,4-dihydroquinoline-3-carboxylic acid is a heterocyclic building block that commonly used in organic synthesis. An example is empolyed in the preparation of VX-770 as a potent CFTR corrector for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation.
Tautomerism and Magnesium Chelation of HIV-1 Integrase Inhibitors: A Theoretical Study. [1]
Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809. [2]
References:
[1] C.Liao, et al, ChemMedChem, 2010, 5(7), pp 1053-1066.
[2] J.E.Doiron, et al, Chemistry, 2019, 25(14), pp 3662-3674.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P305+P351+P338
2933491090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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