4-Pyrazolecarboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1H-Pyrazole-4-carboxylic acid
Nonfluorochemicals, API&Intermediates
KUMI0F238
37718-11-9
MFCD00011558
3015937
110899
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-Pyrazolecarboxylic acid
C4H4N2O2
112.09
≥98%
White to Off-white Solid
273-275°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
4-Pyrazolecarboxylic acid is commonly used as intermediate in the preparation of various pharmaceutically active substances, such as Itacitinib (also named as INCB39110, INCB039110), which is a potent and selective inhibitor of JAK1 tyrosine kinase inhibitor in the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.
A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis. [1]
Reference:
[1] R.Bissonnette, et al, J. Dermatolog. Treat., 2016, 27(4), pp 332-338.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933199090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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