4-Pyrazolecarboxylic acidis commonly used as intermediate in the preparation of various pharmaceutically active substances, such as Itacitinib (also named as INCB39110, INCB039110), which is a potent and selective inhibitor of JAK1tyrosine kinase inhibitor in the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.
A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis. 
 R.Bissonnette, et al, J. Dermatolog. Treat., 2016, 27(4), pp 332-338.
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