4H-Pyrido[1,2-a]pyrimidin-4-one

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4-Oxo-4H-pyridino[1,2-a]pyrimidine
Nonfluorochemicals, API&Intermediates
KUMI0F295
23443-10-9
MFCD07434961

Rea
354785

Reax
116464
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4H-Pyrido[1,2-a]pyrimidin-4-one
C8H6N2O
146.15
98%
White to Yellow Solid
126-129°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
4H-Pyrido[1,2-a]pyrimidin-4-one is a heterocyclic intermediate that commonly used in organic synthesis. One recent example is employed in the preparation of RG7916 as a selective survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the treatment of spinal muscular atrophy (SMA).
Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs. [1]
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA). [2]
References:
[1] A.Poirier, et al, Pharmacol. Res. Perspect, 2018, 6(6):e00447.
[2] H.Ratni, et al, J. Med. Chem., 2019, 61(15), pp 6501-6517.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P305+P351+P338
29339980
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.