5-Acetyl-2-bromopyridine is a heterocyclic intermediate typically used in the prepartion of BLU-667 as a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. [1]
Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. [2]
References:
[1] V.Subbiah, et al, Cancer Discov., 2018, 8(7), pp 836-849.
[2] Z.Piotrowska, et al, Cancer Discov., 2018, 8(12), pp 1529-1539.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933399990
NONH for all modes of transport
1. Product Specification
2. Safety Data Sheet
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