5-Acetyl-2-bromopyridine

Synonym

Product Category

Product Code

CAS Number

MDL Number

Pubchem CID

Reaxys RN

1-(6-Bromopyridin-3-yl)ethanone

Nonfluorochemicals, API&Intermediates

KUMI0F253

139042-59-4

MFCD04974527

15668195

5328913

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Specification
Applications
Safety & Regulations
Product Documents

Chemical Name

Molecular Formula

Molecular Weight

Assay

Appearance

Melting Point

Packaging

Storage

5-Acetyl-2-bromopyridine

C7H6BrNO

200.03

≥98%

White to Yellow Solid

124-128°C

5g,10g,20g,50g,100g,500g and 1kg

Store at room temperature

5-Acetyl-2-bromopyridine is a heterocyclic intermediate typically used in the prepartion of BLU-667 as a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.

Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. [1]

Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. [2]

References:

[1] V.Subbiah, et al, Cancer Discov., 2018, 8(7), pp 836-849.

[2] Z.Piotrowska, et al, Cancer Discov., 2018, 8(12), pp 1529-1539.

Signal Word

Hazard Statements

Precautionary Statements

HS Code

RIDADR

Legal Information

Warning

H315,H319,H335

P261,P305+P351+P338

2933399990

NONH for all modes of transport

1. Product Specification

2. Safety Data Sheet

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