5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole
Nonfluorochemicals, API&Intermediates
KUMI0F259
330792-70-6
MFCD28137676
22346784
20017126
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
C16H12N4O
276.30
≥95%
White to Yellow Solid

5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile is a heterocyclic intermediate that typically used in the preparation of ACP-196, a selective second-generation BTK inhibitor.
Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SAR. [1]
Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor. [2]
References:
[1] T.Takayama, et al, Bioorg. Med. Chem. Lett., 2010, 20(1), pp 112-116.
[2] J.Wu, et al, J. hematol. Oncol., 2016, 9, pp 21-24.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H312,H315,H319,H335
P260,P280,P301+P312,P302+P352,P304+P340
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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