5-Chlorobenzoxazole

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-Chloro-1,3-benzoxazole
Nonfluorochemicals, API&Intermediates
KUMI0F304
17200-29-2
MFCD00216939

Rea
28398

Reax
971560
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
5-Chlorobenzoxazole
C7H4ClNO
153.57
98%
White to Pale Yellow Solid (Crystal Lump)
42-46°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
5-Chlorobenzoxazole is a heterocyclic building block that commonly used in oragnic synthesis. Recently it is typically employed as an intermediate in the preparation of a dual orexin hypocretin receptor (OXR) antagonist for the treatment of insomnia.
Discovery and development of orexin receptor antagonists as therapeutics for insomnia. [1]
Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice. [2]
Suvorexant, a dual orexin receptor antagonist for the management of insomnia. [3]
Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine. [4]
References:
[1] C.J.Winrow, et al, Br. J. Pharmacol., 2014, 171(2), pp 283-293.
[2] K.Etori, et al, Front Neurosci., 2014, 8:8. doi: 10.3389/fnins.2014.00008.
[3] T.Bennett, et al, P.T., 2014, 39(4), pp 264-266.
[4] T.A.Gentile, et al, Addict. Biol., 2018, 23(1), pp 247-255.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P305+P351+P338
2934999090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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