5-Cyclopropyl-1H-imidazole is an intermediate commonly used in the prepartion of some pharmaceutically active substances, such as H3 histamine receptor ligands and apoptosis sigsomenal-regulating kinase 1 (ASK1) inhibitors.
Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: Key intermediates for H3 histamine receptor ligands. [1]
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. [2]