5-Methyl-1,4-diazepane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Hexahydro-5-methyl-1H-1,4-diazepine
Nonfluorochemicals, API&Intermediates
KUMI0F305
22777-05-5
MFCD09607985

Rea
18545617

Reax
605428
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
5-Methyl-1,4-diazepane
C6H14N2
114.19
98%
White to Pale Yellow Solid (Crystal Lump)
175-176°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
5-Methyl-1,4-diazepane is typically employed as an intermediate in the preparation of a dual orexin hypocretin receptor (OXR) antagonist for the treatment of insomnia.
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. [1]
Discovery and development of orexin receptor antagonists as therapeutics for insomnia. [2]
Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice. [3]
Suvorexant, a dual orexin receptor antagonist for the management of insomnia. [4]
Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine. [5]
References:
[1] J.Gunzner-Toste, et al, Bioorg. Med. Chem. Lett., 2013, 23(12), pp 3531-3538.
[2] C.J.Winrow, et al, Br. J. Pharmacol., 2014, 171(2), pp 283-293.
[3] K.Etori, et al, Front Neurosci., 2014, 8:8. doi: 10.3389/fnins.2014.00008.
[4] T.Bennett, et al, P.T., 2014, 39(4), pp 264-266.
[5] T.A.Gentile, et al, Addict. Biol., 2018, 23(1), pp 247-255.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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