(5S)-1-Aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(S)-3,3-Dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
Nonfluorochemicals, API&Intermediates
KUMI0F301
99208-71-6
MFCD26940310

Rea
10898929

Reax
5250008
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(5S)-1-Aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane
C8H13NO2
155.20
98%(99%ee)
Colorless to Light Yellow Liquid (Viscous)
24-25°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
(5S)-1-Aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane is a heterocyclic intermediate that typcially used in the preparation of PF06650833 as an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4) in the treatment of Waldenstrom macroglobulinemia, rheumatoid arthritis, lupus, and lymphomas.
Future therapeutic options for patients with Waldenström macroglobulinemia. [1]
Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015). [2]
Kinase inhibitors in clinical practice: An expanding world. [3]
Improvements to Enable the Large Scale Synthesis of 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833). [4]
References:
[1] J.J.Castillo, et al, Best Pract. Res. Clin. Haematol., 2016, 29(2), pp 206-215.
[2] W.M.Seganish, Expert Opin. Ther. Pat., 2016, 26(8), pp 917-932.
[3] R.Pandey, et al, J. Allergy Clin. Immunol., 2018, 141(2), pp 522-524.
[4] S.W.Wright, et al, Org. Process Res. Dev., 2018, 22(12), pp 1835-1845.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H303,H320
P305+P351+P338
29143900
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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