6,10-Dioxaspiro[4.5]decane-7,9-dione is a useful heterocyclic building block that is typically used in the synthesis of oxaspirocyclic compounds as pharmaceutically and radiopharmaceutical active substances.
Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. 
Facile synthesis of para-[18F]fluorohippurate via iodonium ylide-mediated radiofluorination for PET renography. 
Fluorine-18-Labeled Antagonist for PET Imaging of Kappa Opioid Receptors. 
A Novel 18F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary Evaluation in Nonhuman Primates. 
Design and crystal structures of two new compounds fused with 3,4,5-trimethoxybenzyl group and 6,10-dioxaspiro group. 
 V.M.Carneiro, et al, Eur. J. Med. Chem., 2015, 97, pp 42-54.