6,10-Dioxaspiro[4.5]decane-7,9-dione

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-Tetramethylene-4,6-dioxo-1,3-dioxane
Nonfluorochemicals, [18F] Labelling Precursors
KUMI0F357
58093-05-3
MFCD01617888
2771934
133070
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
6,10-Dioxaspiro[4.5]decane-7,9-dione
C8H10O4
170.16
≥98%
White to Off-White Solid
74-76°C
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
6,10-Dioxaspiro[4.5]decane-7,9-dione is a useful heterocyclic building block that is typically used in the synthesis of oxaspirocyclic compounds as pharmaceutically and radiopharmaceutical active substances.
Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. [1]
Facile synthesis of para-[18F]fluorohippurate via iodonium ylide-mediated radiofluorination for PET renography. [2]
Fluorine-18-Labeled Antagonist for PET Imaging of Kappa Opioid Receptors. [3]
A Novel 18F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary Evaluation in Nonhuman Primates. [5]
Design and crystal structures of two new compounds fused with 3,4,5-trimethoxybenzyl group and 6,10-dioxaspiro group. [4]
References:
[1] V.M.Carneiro, et al, Eur. J. Med. Chem., 2015, 97, pp 42-54.
[2] G.N.Nkepang, et al, Bioorg. Med. Chem. Lett., 2016, 26(2), pp 479-483.
[3] Z.Cai, et al, ACS Chem. Neurosci., 2017, 8(1), pp 12-16.
[4] W.Zeng, et al, Crystals, 2018, 8(4), pp art. no. 146.
[5] E.Baum, et al, ACS Chem. Neurosci., 2018, 10(5), pp 2450-2458.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2932990090
NONH for all modes of transport

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