6-Chloro-2,8-dimethyl-imidazo[1,2-b]pyridazine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
6-Chloranyl-2,8-dimethyl-imidazo[1,2-b]pyridazine
Nonfluorochemicals, API&Intermediates
KUMI0F292
17412-23-6
 

Rea
12248340

Reax
1567861
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
6-Chloro-2,8-dimethyl-imidazo[1,2-b]pyridazine
C8H8ClN3
181.62
98%
White to Yellow Solid
117-119°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
6-Chloro-2,8-dimethyl-imidazo[1,2-b]pyridazine is a heterocyclic intermediate that typically used in the preparation of RG7916 as a selective survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the treatment of spinal muscular atrophy (SMA).
Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs. [1]
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA). [2]
References:
[1] A.Poirier, et al, Pharmacol. Res. Perspect, 2018, 6(6):e00447.
[2] H.Ratni, et al, J. Med. Chem., 2019, 61(15), pp 6501-6517.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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