4-Amino-2,6-dichlorophenol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,5-Dichloro-4-hydroxyaniline
Nonfluorochemicals, API&Intermediates
KUMI0F298
5930-28-9
MFCD00007875

Rea
80037

Reax
2361665
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4-Amino-2,6-dichlorophenol
C6H5Cl2NO
178.02
98%
White to Tan Solid
167-170°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
4-Amino-2,6-dichlorophenol is a useful intermediate that commonly used in the preparation of various drug substances. A typical example is employed to prepare MGL-3196 as a potent and highly selective thyroid hormone receptor β agonist for the treatment of dyslipidemia.
Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196,a liver-targeted thyroid hormone receptor-β agonist. Atherosclerosis. [1]
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia. [2]
References:
[1] R.Taub, et al, Atherosclerosis, 2013, 230(2), pp 373-380.
[2] M.J.Kelly, et al, J. Med. Chem., 2014, 57(10), pp 3912-3923.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2922290090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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