Cyclopropanecarbonyl chloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Cyclopropanecarboxylic acid chloride
Non-Fluorochemicals, API & Intermediates
KUMI0F989
4023-34-1

PubChem ID

Reax
MFCD00001277

PubChem ID
77637
471286
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Cyclopropanecarbonyl chloride
C4H5ClO
104.53
≥98%
Colorless to Red or Green Liquid
117-119°C
10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
Cyclopropanecarbonyl chloride (also known as Cyclopropanecarboxylic acid chloride) is primarily used an intermediate in the manufacture of pharmaceutical and agrochemical products. e.g. Olaparib (AZD-2281, KU-59436), a small molecule inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities.
The influence of substituents on the geometry of the cyclopropane ring. VI The molecular and crystal structures of cyclopropanecarboxylic acid and cyclopropanecarbonyl chloride. [1]
SAR Studies of 3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one as Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase. [2]
4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A novel bioavailable inhibitor of Poly(ADP-ribose) polymerase-1. [3]
Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry. [4]
References:
[1] J.S.A.M. De Boer, et al, Recl. Trav. Chim. Pays-Bas, 1992, 111(9), pp 407-410.
[2] Y-L, Lin, et al, Bioorg. Med. Chem., 2002, 10(3), pp  685-690.
[3] K.A.Menear, et al, J. Med. Chem., 2008, 51(20), pp 6581-6591.
[4] D.Davar, et al, Curr. Med. Chem., 2012, 19(23), pp 3907-3921.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H226,H314
P280,P305+P351+P338,P310
29162000
UN 2920 3(8)/PG II

1. Product Specification
2. Safety Data Sheet
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