1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (also named as DOTA, Tetraxetan) is a orgnic acid commonly used as chelating agent and MOF ligand in organic synthesis. e.g. it can be employed as a chelating agent in the preparation of gadolinium-based MRI contrast agent (GBCA).
An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA. 
GdIII complexes with fast water exchange and high thermodynamic stability: potential building blocks for high-relaxivity MRI contrast agents. 
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. 
The synthesis and chelation chemistry of DOTA- peptide conjugates. 
Preparation of carbon nanotube bioconjugates for biomedical applications. 
 M.R.Lewis, et al, Bioconjug. Chem., 2001, 12(2), pp 320-324.
 S.Laus, et al, Chemistry, 2003, 9(15), pp 3555-3556.
 Z.Liu, et al, Nat. Nanotechnol., 2007, 2(1), pp 47-52.