Ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester
Nonfluorochemicals, API&Intermediates
KUMI0F256
174072-89-0
MFCD04115279
15541848
9275091
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate
C14H14N2O4S
306.33
≥98%
Red to Dark Red Solid
168-170°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
Ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate is a heterocyclic intermediate that commonly used in the preparation of various pharmaceutically active substances, such as TAK-385, a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist administered orally in the treatment of uterine fibroids.
Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists. [1]
Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor. [2]
Synthesis and biological evaluation of novel thieno[2,3-d]pyrimidine-based FLT3 inhibitors as anti-leukemic agents. [2]
References:
[1] Z.Guo, et al, Bioorg. Med. Chem. Lett., 2003, 13(20), pp 3617-3622,
[2] K.Miwa, et al, J. Med. Chem., 2011, 54(14), pp 4998-5012.
[2] J.S.Yang, et al, Eur. J. Med. Chem., 2014, 85, pp 399-407.
Signal Word
Hazard Statements
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HS Code
RIDADR
Legal Information
Not classified as a hazardous substance or mixture


2934999090
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