L-Alanine benzyl ester hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Benzyl (2S)-2-aminopropanoate hydrochloride
Nonfluorochemicals, API&Intermediates
KUMI0F277
5557-83-5
MFCD00054340

Rea
12210893

Reax
3916314
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
L-Alanine benzyl ester hydrochloride
C10H14ClNO2
215.68
98%
White to Off-white Solid
138-140°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
L-Alanine benzyl ester hydrochloride was used as an organic reagent and as a cationic charge inducer in microemulsions. It is most recently used
in the preparation of NUC-1031, a phosphoramidate modification of gemcitabine, as a new ProTide for the first-line treatment of advanced biliary tract cancer.
Positively charged microemulsions for topical application. [1]
The Benzyl Ester Group of Amino Acid Monomers Enhances Substrate Affinity and Broadens the Substrate Specificity of the Enzyme Catalyst in Chemoenzymatic Copolymerization. [2]
Application of ProTide technology to gemcitabine: A successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development. [3]
A phosphoramidate ProTide (NUC-1031) and acquired and intrinsic resistance to gemcitabine. [4]
Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study. [5]
References:
[1] E.Peira, et al, Int. J. Pharm., 2008, 346(1-2), pp 119-123.
[2] J.M.Ageitos, et al, Biomacromolecules, 2016, 17(1), pp 314-323.
[3] M.Slusarczyk, et al, J. Med. Chem., 2014, 57(4), pp 1531-1542.
[4] C.McGuigan, et al, J. Clin. Oncol., 2016, 29(15 Suppl.), e13540.
[5] S.P.Blagden, et al, 2018, 119, pp 815-822.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a hazardous substance or mixture


2922498590
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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