Methyl 3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-Cyclopropylmethoxy-4-methanesulfonylaminobenzoic acid methyl ester
Non-Fluorochemicals, API & Intermediates
KUMI0F975
1239278-73-9

PubChem ID

Reax
 

PubChem ID
 
20491291
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Methyl 3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoate
C13H17NO5S
299.35
≥95%
White to Brown Solid
 
10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperature
Methyl 3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoate (also named as 3-Cyclopropylmethoxy-4-methanesulfonylaminobenzoic acid methyl ester) is typically used in the preparation of CHF6001, a novel highly potent and selective phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease (COPD).
Process development of the PDE4 inhibitor K-34. [1]
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration. [2]
Synthesis of 14C- and 2H-labelled CHF6001: A new potent PDE4 inhibitor. [3]
References:
[1] A.Yanagisawa, et al, Org. Process Res. Dev., 2011, 15(2), pp 376-381.
[2] N.Moretto, et al, J. Pharmcol. Exp. Ther., 2015, 352(3), pp 559-567.
[3] E.Fontana, et al, J. Label. Compd. Radiooharm., 2017, 60(12), pp 577-585.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not regulated
 
 
29359090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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