Methyl 6-chloro-pyridine-2-carboxylate is a heterocyclic intermediate that typically used in the preparation of AG-881 as a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) for patients with IDH mutation-positive hematologic malignancies and solid tumors, and Apoptosis signal-regulating kinase 1 (ASK1) Inhibitors as Potential Agents for Heart Failure.
Synthesis of 2,2′‐Bipyridines: Versatile Building Blocks for Sexy Architectures and Functional Nanomaterials. 
The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors. 
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. 
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