Methyl 6-chloro-pyridine-2-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Methyl 6-chloropicolinate, 6-Chloropicolinic Acid Methyl Ester
Nonfluorochemicals, API&Intermediates
KUMI0F288
6636-55-1
MFCD00155391

Rea
242723

Reax
128580
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Methyl 6-chloro-pyridine-2-carboxylate
C7H6ClNO2
171.58
98%
White to Off-white Solid
93-97°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
Methyl 6-chloro-pyridine-2-carboxylate is a heterocyclic intermediate that typically used in the preparation of AG-881 as a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) for patients with IDH mutation-positive hematologic malignancies and solid tumors, and Apoptosis signal-regulating kinase 1 (ASK1) Inhibitors as Potential Agents for Heart Failure.
Synthesis of 2,2′‐Bipyridines: Versatile Building Blocks for Sexy Architectures and Functional Nanomaterials. [1]
The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors. [2]
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. [3]
References:
[1] G.R.Newkome, et al, Eur. J. Org. Chem., 2004, 2, pp 235-254.
[2] J.Chen, et al, Mini Rev. Med. Chem., 2016, 16(16), pp 1344-1358.
[3] M.Lanier, et al, ACS Med. Chem. Lett., 2017, 8(3), pp 316-320.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P305+P351+P338
2933399990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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