Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
8-Methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid methyl ester
Nonfluorochemicals, API&Intermediates
KUMI0F252
2097133-36-1
 
129088609
31224578
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate
C11H18O5
230.26
≥98%
White to Yellow Solid

5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate is a heterocyclic intermediate typically used in the prepartion of BLU-667 as a potent and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. [1]
Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. [2]
References:
[1] V.Subbiah, et al, Cancer Discov., 2018, 8(7), pp 836-849.
[2] Z.Piotrowska, et al, Cancer Discov., 2018, 8(12), pp 1529-1539.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338,P302+P352
2932999090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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