N-Cyanoacetylurethane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Ethyl cyanoacetylcarbamate
Nonfluorochemicals, API&Intermediates
KUMI0F297
6629-04-5
MFCD00001937

Rea
23112

Reax
1210605
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
N-Cyanoacetylurethane
C6H8N2O3
156.14
98%
White to Light Yellow Solid
167-169°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
N-Cyanoacetylurethane is a heterocyclic intermediate that typically used in the preparation of MGL-3196 as a potent and highly selective thyroid hormone receptor β agonist for the treatment of dyslipidemia.
Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196,a liver-targeted thyroid hormone receptor-β agonist. Atherosclerosis. [1]
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia. [2]
References:
[1] R.Taub, et al, Atherosclerosis, 2013, 230(2), pp 373-380.
[2] M.J.Kelly, et al, J. Med. Chem., 2014, 57(10), pp 3912-3923.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H312,H315,H319,H332,H335
P261,P280,P305+P351+P338
29269070900
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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