N-Methoxy-N-methylacetamide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-methyl-N-methoxyacetamide, N-Acetyl-N,O-dimethylhydroxylamine
Nonfluorochemicals, Acetylating Reagent
KUMI0F359
78191-00-1
MFCD00060098
537505
3600878
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
N-Methoxy-N-methylacetamide
C4H9NO2
103.12
≥98%
Colorless to Light Yellow Liquid
93-94°C/100mmHg
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
N-Methoxy-N-methylacetamide (also named as N-methyl-N-methoxyacetamide, N-Acetyl-N,O-dimethylhydroxylamine) is typically used as a acetylating reagent in organic synthsis, e.g. in the preparation of the pharmaceutically active substance of BYL719.
Acetylations of strongly basic and nucleophilic enolate anions with N-methoxy-N-methylacetamide. [1]
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands. [2]
Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer. [3]
References:
[1] A.Timothy, et al, Tetrahedron Lett., 1983, 24(18), pp 1851-1854.
[2] X.Z.Zhao, et al, Bioorg. Med. Chem., 2006, 14(23), pp 7816-7825.
[3] F.Andre, et al, New Engl. J. Med., 2019, 380(20), pp 1929-1940.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226

2928009090
UN 1993 3/PG III

1. Product Specification
Available on request.
2. Safety Data Sheet
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