O-phenyl chloromethanethioate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Phenyl chlorothionocarbonate, Chlorothioformic Acid O-Phenyl Ester
Nonfluorochemicals
KUMI0F344
1005-56-7
MFCD00004920
70498
774830
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
O-phenyl chloromethanethioate
C7H5ClOS
172.63
≥98%
Pale Yellow to Deep Yellow Liquid
81-83°C/6mmHg
5g,10g,20g,50g,100g,500g,1kg and 25kg
Store at 2-8°C temp.
O-phenyl chloromethanethioate (also named as Phenyl chlorothionocarbonate, Chlorothioformic Acid O-Phenyl Ester) is typically used as a reagent  in the peptide synthsis, e.g. It has been used in the stereodirected synthesis of optically active, (−)-mintlactone and the synthesis of peptide α-thioesters having a variety of C-terminal amino acids.
Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation. [1]
A synthetic approach to a peptide α-thioester from an unprotected peptide through cleavage and activation of a specific peptide bond by N-acetylguanidine. [2]
References:
[1] Y.Sun, et al, Bioorg. Med. Chem., 2008, 16(15), pp 7177-7184.
[2] R.Okamoto, et al, Angew. Chem. Int. Ed. Engl., 2012, 51(1), pp 191-196.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314
P280,P305+P351+P338,P310
2930909899
UN 3265 8/PG II

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2. Safety Data Sheet
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