(R)-2-Methyl-CBS-oxazaborolidine 

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine
Non-Fluorochemicals, CBS Catalysts
KUMI0F82
112022-83-0

PubChem ID

Reax
MFCD00078440

PubChem ID
9838490
9059874
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(R)-2-Methyl-CBS-oxazaborolidine
C18H20BNO
277.17
≥97%(99%ee) (1M Soln in toluene also provided)
White to Pale yellow Solid
85-95°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Precipitate may form in storage, but does not affect product quality.
(R)-2-Methyl-CBS-oxazaborolidine (also named as (R)-Me-CBS Catalyst) is used as CBS (Corey-Bakshi-Shibata) catalyst in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids,α-amino acids, C2 symmetrical ferrocenyl diols, and propargyl alcohols.
Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl Ketones. [1]
Oxazaborolidine mediated asymmetric ketone reduction: prediction of enantiomeric excess based on catalyst structure. [2]
Total Synthesis of (+)-Lyconadin A and Related Compounds via Oxidative C−N Bond Formation. [3]
References:
[1] K.A.Parker, et al, J. Org. Chem., 1996, 61(9), pp 3214-3217.
[2] M.Hoogenraad, et al, Tetrahedron:Asymmetry, 2004, 15(3), pp 519-523.
[3] S.P.West, et al, J. Am. Chem. Soc., 2009, 131(31), pp 11187-11194.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H225,H304,H315,H336,H361d,H373
P210,P261,P280,P301+P310,P331
3815909090
UN 1294 3/PG II

1. Product Specification
2. Safety Data Sheet
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