Pyridine-3-sulfonyl chloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-Pyridinesulfonyl chloride, 3-Pyridylsulfonyl chloride
Nonfluorochemicals, API&Intermediates
KUMI0F302
16133-25-8
MFCD03452747

Rea
3164136

Reax
120820
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Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Pyridine-3-sulfonyl chloride
C5H4NSO2Cl
177.61
98%
Colorless to Light Brown Liquid
134-136°C/20mmHg
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
Pyridine-3-sulfonyl chloride is commonly used as a derivatization reagent in HPLC or LC-MS analysis. Recently it is also employed in the preparation of TAK-438 as a novel potassium-​competitive acid blocker for the treatment of acid-​related diseases.
Analysis of steroidal estrogens as pyridine-3-sulfonyl derivatives by liquid chromatography electrospray tandem mass spectrometry. [1]
Chemical derivatization to enhance ionization of anabolic steroids in LC-MS for doping-control analysis. [2]
Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamin e fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). [3]
Vonoprazan: first global approval. [4]
Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438). [5]
Development of a stability- indicating HPLC method for simultaneous determination of ten related substances in vonoprazan fumarate drug substance. [6]
References:
[1] L.Xu, et al, Anal. Biochem., 2008, 375(1), pp 105-114.
[2] I.Athanasiadou, et al, Trends Anal. Chem., 2013, 42, pp 137-156.
[3] Y.Arikawa, et al, J. Med. Chem., 2012, 55(9), pp 4446-4456.
[4] K.P.Garnock-Jones, Drugs, 2015, 75(4), pp 439-443.
[5] K.Otake, et al, Adv. Ther., 2016, 33(7), pp 1140-1157.
[6] Z.Luo, et al, J. Pharm. Biomed. Anal., 2018, 149, pp 133-142
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314
P260,P280,P305+P351+P338
2933399990
UN 3265 8/PG II

1. Product Specification
2. Safety Data Sheet
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