Pyridine-3-sulfonyl chloride is commonly used as a derivatization reagent in HPLC or LC-MS analysis. Recently it is also employed in the preparation of TAK-438 as a novel potassium-competitive acid blocker for the treatment of acid-related diseases.
Analysis of steroidal estrogens as pyridine-3-sulfonyl derivatives by liquid chromatography electrospray tandem mass spectrometry. 
Chemical derivatization to enhance ionization of anabolic steroids in LC-MS for doping-control analysis. 
Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamin e fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).