(R)-2-(1H-indol-3-yl)-1-methyl-ethylamine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(R)-α-Methyltryptamine, (R)αMT, (R)AMT
Nonfluorochemicals, API&Intermediates
KUMI0F308
7795-52-0
MFCD13183876
448779
5257465
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(R)-2-(1H-indol-3-yl)-1-methyl-ethylamine
C11H14N2
174.25
≥98%
White to Yellow Solid
103-105°C
5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
(R)-2-(1H-indol-3-yl)-1-methyl-ethylamine (also known as (R)-α-Methyltryptamine) is a chiral methylated Tryptamine with psychedelic, stimulant and entactogenic properties. It is a non-selective serotonin receptor agonist and acts as relatively balanced releasing agent of serotonin, norepinephrine, and dopamine. Recently it is also used as an intermediate to synthesis GDC-9545 (RG6171), which is a selective estrogen receptor degrader (SERD) that is designed to bind to the estrogen receptor to limit its function.
The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. [1] 
In vitro screening of psychoactive drugs by [(35)S]GTPgammaS binding in rat brain membranes. [2] 
The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. [3]
References:
[1] F.Nagai, et al, Eur. J. Pharmcol., 2007, 559(2-3), pp 132-137.
[2] R.Nonaka, et al, Biol. Pharm. Bull., 2007, 30(12), pp 2328-2333.
[3] J.D.Joseph, et al, eLife, 2016, 5:e15828.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a hazardous substance or mixture


29335995
NONH for all modes of transport

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