(R)-3-Methyl-2-oxo-piperazine

Synonym

Product Category

Product Code

CAS Number

MDL Number

Pubchem CID

Reaxys RN

(R)-3-Methyl-2-ketopiperazine

Nonfluorochemicals, API&Intermediates

KUMI0F263

922178-61-8

MFCD07373460

16213757

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png

Specification
Applications
Safety & Regulations
Product Documents

Chemical Name

Molecular Formula

Molecular Weight

Assay

Appearance

Melting Point

Packaging

Storage

(R)-3-Methyl-2-oxo-piperazine

C5H10N2O

114.15

≥99%(ee ≥96%)

White to Off-white Solid

5g,10g,20g,50g,100g,500g and 1kg

Store at room temperature

(R)-3-Methyl-2-oxo-piperazine is a heterocyclic intermediate that typically used in the preparation of Fezolinetant (ESN-364), a a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist for the treatment of sex hormone-related disorders.

Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II). [1]

The NK3 Receptor Antagonist ESN364 Suppresses Sex Hormones in Men and Women. [2]

References:

[1] H.R.Hoveyda, et al, ACS Med. Chem. Lett., 2015, 6(7), pp 736-740.

[2] G.L.Fraser, et al, J. Clin. Endocrinol. Metab., 2016, 101(2), pp 417-426.

Signal Word

Hazard Statements

Precautionary Statements

HS Code

RIDADR

Legal Information

Warning

H319,H334

P261,P305+P351+P338,P342+P311

2933599590

NONH for all modes of transport

1. Product Specification

2. Safety Data Sheet

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