(R)-3-Methyl-2-oxo-piperazine is a heterocyclic intermediate that typically used in the preparation of Fezolinetant (ESN-364), a a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist for the treatment of sex hormone-related disorders.
Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II). [1]
The NK3 Receptor Antagonist ESN364 Suppresses Sex Hormones in Men and Women. [2]