(R)-3-Methyl-2-oxo-piperazine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(R)-3-Methyl-2-ketopiperazine
Nonfluorochemicals, API&Intermediates
KUMI0F263
922178-61-8
MFCD07373460
16213757
 
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(R)-3-Methyl-2-oxo-piperazine
C5H10N2O
114.15
≥99%(ee ≥96%)
White to Off-white Solid

5g,10g,20g,50g,100g,500g and 1kg
Store at room temperature
(R)-3-Methyl-2-oxo-piperazine is a heterocyclic intermediate that typically used in the preparation of Fezolinetant (ESN-364), a a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist for the treatment of sex hormone-related disorders.
Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II). [1]
The NK3 Receptor Antagonist ESN364 Suppresses Sex Hormones in Men and Women. [2]
References:
[1] H.R.Hoveyda, et al, ACS Med. Chem. Lett., 2015, 6(7), pp 736-740.
[2] G.L.Fraser, et al, J. Clin. Endocrinol. Metab., 2016, 101(2), pp 417-426.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H319,H334
P261,P305+P351+P338,P342+P311
2933599590
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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