(R)-3-Pyrrolidinol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(R)-3-Hydroxypyrrolidine
Nonfluorochemicals, API&Intermediates
KUMI0F274
2799-21-5
MFCD00145220

Rea
2759337

Reax
4173962
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
(R)-3-Pyrrolidinol
C4H9NO
87.12
98%(99 ee%)
Colorless to Yellow Liquid
215-216°C
5g,10g,25g,50g,100g,250g,500g,1kg and 25kg
Store at room temperture
(R)-3-Pyrrolidinol is a heterocyclic building block that commonly used in organic synthesis. one example is employed in the preparation of ABL001 as a potent and selective allosteric BCR-ABL1 inhibitor for the treatment of Chronic myelogenous leukemia (CML).
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. [1]
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. [2]
Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects. [3]
References:
[1] A.A.Wylie, et al, Nature, 2017, 543(7647), pp 733-737.
[2] J.Schoepfer, et al, J. Med. Chem., 2018, 61(18), pp 8120-8135.
[3] P.Tran, et al, Xenobiotica, 2019, 1594449, doi: 10.1080/00498254.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933998090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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