(R)-3-Pyrrolidinol is a heterocyclic building block that commonly used in organic synthesis. one example is employed in the preparation of ABL001 as a potent and selective allosteric BCR-ABL1 inhibitor for the treatment of Chronic myelogenous leukemia (CML).
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. 
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. 
Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects. 
 A.A.Wylie, et al, Nature, 2017, 543(7647), pp 733-737.
 J.Schoepfer, et al, J. Med. Chem., 2018, 61(18), pp 8120-8135.
 P.Tran, et al, Xenobiotica, 2019, 1594449, doi: 10.1080/00498254.
NONH for all modes of transport
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