(S)-(−)-α-Methylbenzyl isocyanate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(S)-(−)-1-Phenylethyl isocyanate
Non-Fluorochemicals, Chiral Derivatizing Agents
KUMI0F213
14649-03-7
MFCD00002036
2724173
4230972
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
(S)-(−)-α-Methylbenzyl isocyanate
C9H9NO
147.17
≥97% (ee 98%)
Colorless to Pale Yellow Liquid
55-56°C/2.5 mmHg(lit.)
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at 2-8°C temp.
(S)-(−)-α-Methylbenzyl isocyanate is a chiral derivatizing agent commonly used for the resolution of enantiomers.
Resolution of salbutamol enantiomers in human urine by reversed-phase high performance liquid chromatography after derivatization with (S)-(-)-alpha-methylbenzyl isocyanate. [1]
Derivatization of (+/-)-5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate for drug monitoring purposes. [2]
References:
[1] K.H.Kim, et al, Arch. Pharm. Res., 1997, 20(5), pp 486-490.
[2] M.Matoga, et al, J. Enzyme Inhib. Med. Chem., 2002, 17(6), pp 375-379.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H315,H319,H331,H330,H334,H335
P260,P284,P305+P351+P338,P310
2929100090
UN 2206 6.1/PG III

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2. Safety Data Sheet
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